Endocrine Abstracts

Introduction: According to NICE: adults receiving GH treatment, IGF1 levels should reach therapeutic range by 9 months. Patients are reviewed at 1, 3, 6, 9, 12 months and 6 months thereafter in our clinics. GH dose is titrated by 0.1 mg each visit. This work aims to compare the time it takes to get the IGF1 in range, between adults and adolescent patients attending our specialist regional clinics.Method: We performed a retrospective audit of 20 patients ...

Successful embryo implantation requires changes in endometrial gene expression of biomarkers which contribute to uterine receptivity to facilitate blastocyst attachment. Osteopontin (OPN), expressed at the maternal–foetal interface may facilitate implantation in processes, such as cell adhesion, migration and angiogenesis which require OPN signalling via CD44 and integrin receptors. As coordinate expression of OPN and receptors is shown to be cycle-dependent and up-regula...

Background: Topical corticosteroids (TCs) are widely used as depigmenting agents alone or in combination with other fairness creams. However, its use may cause secondary adrenocortical insufficiency.Objective: The aim of the present study is to evaluate the relationship between practice of whitening creams (Topical Corticosteroids) and serum cortisol level in a sample of healthy females at Ain- shams University hospital.Methods: We...

Aim: To describe the clinical characteristics and outcomes of hospitalized COVID-19 patients with diabetes.Methods: A retrospective cross-sectional study was conducted among patients admitted to the William. Harvey Hospital in England between March 10th and May10th, 2020 with a laboratory confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), known as COVID19. Variation in characteristics, length of stay in hospital, diabetes status, dur...

Background: Subclinical hypothyroidism is a common thyroid disorder. Although there is a recognized association between thyroid disease and diabetes mellitus, there is no definite answer as to whether screening for subclinical hypothyroidism is necessary in patients with type 2 diabetes.Objective: To evaluate the prevalence of subclinical hypothyroidism in women with type 2 diabetes in Egypt.Patients and methods: women with type 2 ...

Introduction: Adrenal metastases due to thyroid cancers deemed to very rare as adrenal glands are not a common site of metastases from thyroid cancer. When the phenomenon occurs the prognosis is very poor as adrenal metastases usually do not fix radioactive iodine. Our aim is to report three cases.Case reports: No. 1: a woman aged 57 harbouring anaplastic thyroid cancer classified T4, N1, M0, consulted for back pain, severe fatigue and skin pigmentation....

At implantation, the ability of an embryo to successfully attach to the luminal epithelium is dependent on the receptive phenotype the endometrium must acquire. This spatially and temporally restricted period of uterine receptivity is defined by endometrial molecular adaptations, highly regulated by embryonic-derived signals and ovarian steroids. Critical to this isthe expression of adhesivemoleculesintegrins and osteopontin (OPN) at the foetal-maternal interface which facilit...

The experiment was designed to study toxic effects of Di-(2-ethylhexyl) phthalate (DEHP) on semen characteristics, testosterone levels, testicular lipid peroxidation and testicular antioxidants in male New-Zealand white rabbits for 12 weeks. Ginger has been reported to be an important antioxidant. Therefore, the protective effect of ginger against DEHP-induced reproductive toxicity and oxidative stress was studied. Rabbits were orally administered the doses of ginger, DEHP and...

Background: Testosterone deficiency (TD) affects 5–6% of men aged 30–79 years and it can be a presenting feature of a serious underlying condition like a pituitary tumour. Clinical practice guidelines have recommended thorough investigative workup of such patients to delineate the underlying pathology in patients with secondary TD. We have undertaken a retrospective study to assess the need for expensive investigations in patients with relatively mild TD suspected to...

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010. Only 5.1% of patients had history of partial thyroidectomy; patients with previous history of RAI for thyrotoxicosis were excluded. All patients received written information leaflet for RAI.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 97.4% were Ca...